This series really likes to milk the dramatic death scenes.

I'm pretty sure it'll be Tatsumi and Akame vs Esdese and Kurome at the end. At this point, it's just seem like the Prime Minister will betray/kill Esdese at some point after she loses to the Nightraid and then pull some typical big bad ultimate form. What would be an interesting twist is that the emperor is the true evil one all along and he was the one manipulating the prime minister.